Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression.

Pharmacogenomics - 1 Sept 2013

Magdy Tarek, Arlanov Rudolf, Winter Stefan, Lang Thomas, Klein Kathrin, Toyoda Yu, Ishikawa Toshihisa, Schwab Matthias, Zanger Ulrich M

Abstract excerpt

AIM: Because 5-fluorodeoxyuridine monophosphate (5-FdUMP), an anabolic active metabolite of 5-fluorouracil (5-FU), is a substrate of MRP8 (encoded by ABCC11), we investigated whether ABCC11 polymorphisms play a role in severe toxicity of 5-FU. PATIENTS & METHODS: Genomic DNA from 672 cancer patients treated with 5-FU monotherapy and with documented toxicity according to WHO criteria was genotyped for 12 ABCC11...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

Share to Gene Expression Regulation, Neoplastic

Share to Leukopenia

Share to Neoplasms

Share to Risk Factors

Source

Identifiers

PMID: 24024896
DOI: 10.2217/pgs.13.139

Genes

ABCC11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression.PMID 24024896Read ↗

The impact of ABCC11 polymorphisms on the risk of early-onset fluoropyrimidine toxicity.Semantic proximity Read ↗

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.Semantic proximity Read ↗

Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.Semantic proximity Read ↗

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug DevelopmentSemantic proximity Read ↗

Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC).Semantic proximity Read ↗

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.Semantic proximity Read ↗

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.Semantic proximity Read ↗

Variability in human hepatic MRP4 expression: influence of cholestasis and genotype.Semantic proximity Read ↗

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.Semantic proximity Read ↗

Case report: severe toxicity in an African-American patient receiving FOLFOX carrying uncommon allelic variants in DPYD.Semantic proximity Read ↗

MRP6 (ABCC6) Detection in Normal Human Tissues and TumorsSemantic proximity Read ↗

The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.