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Article

The impact of ABCC11 polymorphisms on the risk of early-onset fluoropyrimidine toxicity.

The pharmacogenomics journal - 1 Jul 2017

Hamzic S, Wenger N, Froehlich T K, Joerger M, Aebi S, Largiadèr C R, Amstutz U

Abstract excerpt

A missense variant (c.1637C>T, T546M) in ABCC11 encoding the MRP8 (multidrug resistance protein 8), a transporter of 5-fluorodeoxyuridine monophosphate, has been associated with an increased risk of 5-fluorouracil-related severe leukopenia. To validate this association, we investigated the impact of the ABCC11 variants c.1637C>T, c.538G>A and c.395+1087C>T on the risk of early-onset fluoropyrimidine-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27001120
DOI: 10.1038/tpj.2016.23

Genes

ABCC11
DPYD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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