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Article

Case report: severe toxicity in an African-American patient receiving FOLFOX carrying uncommon allelic variants in DPYD.

Pharmacogenomics - 1 Jan 2021

Sissung Tristan M, Cordes Lisa, Peer Cody J, Gandhy Shruti, Redman Jason, Strauss Julius, Figg William D

Abstract excerpt

Cancers of the colon are commonly treated with fluoropyrimidines, which often cause severe toxicities in patients with certain variants in DPYD. Y186C (rs115232898) and a variant in the 3' untranslated region (rs12132152) are uncommon alleles previously observed in African-Americans. An African-American female underwent 5-fluorouracil-based therapy (400 mg/m2 bolus, 1200 mg/m2/day over 46 h). The patient...

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Share to Antimetabolites, Antineoplastic
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Identifiers

PMID: 33305610
DOI: 10.2217/pgs-2020-0120
PMCID: PMC7831885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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