IGFBP2 is a candidate biomarker for <i>Ink4a-Arf</i> status and a therapeutic target for high-grade gliomas

doi:10.1073/pnas.0900807106

Article

IGFBP2 is a candidate biomarker for <i>Ink4a-Arf</i> status and a therapeutic target for high-grade gliomas

16 Sept 2009

Abstract excerpt

The levels of insulin-like growth factor-binding protein 2 (IGFBP2) are elevated during progression of many human cancers. By using a glial-specific transgenic mouse system (RCAS/Ntv-a), we reported previously that IGFBP2 is an oncogenic factor for glioma progression in combination with platelet-derived growth factor-beta (PDGFB). Because the INK4a-ARF locus is often deleted in high-grade gliomas (anaplastic...

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