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Article

Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival

13 May 2009

Abstract excerpt

The three leucine-rich repeats and immunoglobulin-like domains (LRIG) genes encode integral membrane proteins. Of these, LRIG1 negatively regulates growth factor signaling and is implicated as a tumor suppressor in certain malignancies. In astrocytic tumors, the subcellular distribution of LRIG proteins is associated with specific clinicopathological features and patient survival. The role of LRIG proteins in...

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PMID: 18992012
DOI: 10.1111/j.1440-1789.2008.00970.x

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