Article

Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in Diffuse Large B Cell Lymphoma (DLBCL)

2025-09-01

Abstract excerpt

<title>Abstract</title> <p>BCR signal dependency is a hallmark of diffuse large B-cell lymphoma (DLBCL) and other B-cell lymphoid malignancies originating from germinal centers. Chronic-active BCR signaling, typical for the more aggressive activated B-cell subtype (ABC) of DLBCLs, is often attributed to activating mutations within the BCR signaling cascade and continuous stimulation of the BCR by autoantigens. In...

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Literature Corpus work: d91fbc9a-4171-5db9-b407-06b2f98db707
DOI: 10.21203/rs.3.rs-7260543/v1

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