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Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

18 Apr 2024

Abstract excerpt

SYNTAXIN-11 (STX11) is a SNARE protein that mediates the fusion of cytotoxic granules with the plasma membrane at the immunological synapses of CD8 T or NK cells. Autosomal recessive inheritance of deleterious STX11 variants impairs cytotoxic granule exocytosis, causing familial hemophagocytic lymphohistiocytosis type 4 (FHL-4). In several FHL-4 patients, we also observed hypogammaglobulinemia, elevated...

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PMID: 38722309
DOI: 10.1084/jem.20221122

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Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defectPMID 38722309Read ↗

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