Article
Genotype-Guided Dosing of Warfarin in Chinese Adults: A Multicenter Randomized Clinical Trial.
Circulation. Genomic and precision medicine - 1 Aug 2020
Guo Chengxian, Kuang Yun, Zhou Honghao, Yuan Hong, Pei Qi, Li Jingle, Jiang Weihong, Ng Chee M, Chen Xiaoping, Huo Yong, Cui Yimin, Wang Xiaobin, Yu Jingjing, Sun Xue, Yu Wanying, Chen Peng, Miao Da, Liu Wenyu, Yu Zaixin, Ouyang Zewei, Shi Xiangjiang, Lv Chunmei, Peng Zijing, Xiong Guozuo, Zeng Gaofeng, Zeng Jianping, Dai Haiying, Peng Jianqiang, Zhang Yuming, Xu Fanghua, Wu Jie, Chen Xiaoliang, Gong Hao, Yang Zhiyuan, Wu Xianming, Fang Qiulian, Yang Liu, Li Haigang, Tan Hongyi, Huang Zhijun, Tang Xiaohong, Yang Qiong, Tu Shan, Wang Xiaoyan, Xiang Yuxia, Huang Jie, Wang Xiaomin, Cai Jingjing, Jiang Shanjie, Huang Lu, Peng Jinfu, Gong Liying, Zou Chan, Yang Guoping
Abstract excerpt
BACKGROUND: Warfarin is an effective treatment for thromboembolic disease but has a narrow therapeutic index; optimal anticoagulation dosage can differ tremendously among individuals. We aimed to evaluate whether genotype-guided warfarin dosing is superior to routine clinical dosing for the outcomes of interest in Chinese patients. METHODS: We conducted a multicenter, randomized, single-blind, parallel-controlled...
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