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Article

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia.

British journal of haematology - 1 Nov 2013

Jethwa Alexander, Hüllein Jennifer, Stolz Tatjana, Blume Carolin, Sellner Leopold, Jauch Anna, Sill Martin, Kater Arnon P, te Raa G Doreen, Geisler Christian, van Oers Marinus, Dietrich Sascha, Dreger Peter, Ho Anthony D, Paruzynski Anna, Schmidt Manfred, von Kalle Christof, Glimm Hanno, Zenz Thorsten

Abstract excerpt

Recurrent gene mutations contribute to the pathogenesis of chronic lymphocytic leukaemia (CLL). We developed a next-generation sequencing (NGS) platform to determine the genetic profile, intratumoural heterogeneity, and clonal structure of two independent CLL cohorts. TP53, SF3B1, and NOTCH1 were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24032483
DOI: 10.1111/bjh.12539

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24032483-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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