Inheritance of MHC class II genes in IDDM studied in population-based affected and control families.

doi:10.1007/BF00418374

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Article

Inheritance of MHC class II genes in IDDM studied in population-based affected and control families.

Diabetologia - 1 Nov 1994

Kockum I, Wassmuth R, Holmberg E, Michelsen B, Lernmark A

Abstract excerpt

The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p < 0.025) and DQB1*0302 (p < 0.01) from both par...

Topics

Adolescent
Adult
Case-Control Studies
Child
Child, Preschool
Diabetes Mellitus, Type 1
Female
Gene Frequency
Genes, MHC Class II
Genotype
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
Humans
Infant
Infant, Newborn
Male
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 7867882
DOI: 10.1007/BF00418374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7867882-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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