Article
Inheritance of MHC class II genes in IDDM studied in population-based affected and control families.
Diabetologia - 1 Nov 1994
Kockum I, Wassmuth R, Holmberg E, Michelsen B, Lernmark A
Abstract excerpt
The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p < 0.025) and DQB1*0302 (p < 0.01) from both parents to the index patient. There was an increased transmission of DQB1*0302 (p < 0.03) from the mothers only. The...
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