Article
Lack of preferential transmission of diabetic HLA alleles by healthy parents to offspring in Spanish diabetic families.
The Journal of clinical endocrinology and metabolism - 1 Feb 1990
Martin-Villa J M, Vicario J L, Martinez-Laso J, Serrano-Rios M, Lledó G, Damiano A, Hawkins F, Regueiro J R, Arnaiz-Villena A
Abstract excerpt
HLA-DR3 or -DR4 segregation distortion to normal or insulin-dependent (ID) diabetic offspring of 108 Spanish families whose parents were healthy was not observed; however, DR3 or DR4 ID offspring is significantly increased in the present study, since parents were chosen after tracing ID children....
Topics
- Adolescent
- Alleles
- Diabetes Mellitus, Type 1
- Ethnicity
- Family
- Family Health
- Female
- Genotype
- HLA Antigens
- HLA-DR3 Antigen
- HLA-DR4 Antigen
- Humans
- Male
- Phenotype
- Sex Factors
- Spain