Article
Lack of preferential transmission of diabetic HLA alleles by healthy parents to offspring in Spanish diabetic families.
The Journal of clinical endocrinology and metabolism - 1 Feb 1990
Martin-Villa J M, Vicario J L, Martinez-Laso J, Serrano-Rios M, Lledó G, Damiano A, Hawkins F, Regueiro J R, Arnaiz-Villena A
Abstract excerpt
HLA-DR3 or -DR4 segregation distortion to normal or insulin-dependent (ID) diabetic offspring of 108 Spanish families whose parents were healthy was not observed; however, DR3 or DR4 ID offspring is significantly increased in the present study, since parents were chosen after tracing ID children. These results are discrepant with those found by others in families with diabetic parents in other ethnic groups....
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