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Article

A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.

Journal of autoimmunity - 1 Nov 2006

Awdeh Z L, Yunis Edmond J, Audeh Mark J, Fici Dolores, Pugliese Alberto, Larsen Charles E, Alper Chester A

Abstract excerpt

We had earlier hypothesized, if parents originated from previously isolated populations that had selected against different critical susceptibility genes for a polygenic disease, their offspring could have a greater risk of that disease than either parent. We therefore studied parents of patients with type 1 diabetes (T1D). We found that parents who transmitted HLA-DR3 to HLA-DR3/DR4 patients had different HLA-A...

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Identifiers

PMID: 17052889
DOI: 10.1016/j.jaut.2006.08.004

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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