Article
The hemagglutinin mutation E391K of pandemic 2009 influenza revisited.
Molecular phylogenetics and evolution - 1 Jan 2014
Radomski Jan P, Płoński Piotr, Zagórski-Ostoja Włodzimierz
Abstract excerpt
Phylogenetic analyses based on small to moderately sized sets of sequential data lead to overestimating mutation rates in influenza hemagglutinin (HA) by at least an order of magnitude. Two major underlying reasons are: the incomplete lineage sorting, and a possible absence in the analyzed sequences set some of key missing ancestors. Additionally, during neighbor joining tree reconstruction each mutation is...
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