Article
Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects.
Neurobiology of aging - 1 Feb 2014
Millard Steven P, Lutz Franziska, Li Ge, Galasko Douglas R, Farlow Martin R, Quinn Joseph F, Kaye Jeffrey A, Leverenz James B, Tsuang Debby, Yu Chang-En, Peskind Elaine R, Bekris Lynn M
Abstract excerpt
Low cerebrospinal fluid (CSF) Aβ(42) levels correlate with increased brain Aβ deposition in Alzheimer's disease (AD), which suggests a disruption in the degradation and clearance of Aβ from the brain. In addition, APOE ε4 carriers have lower CSF Aβ(42) levels than non-carriers. The hypothesis of this investigation was that CSF Aβ(42) levels would correlate with regulatory region variation in genes that are...
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