Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition.

Archives of neurology - 1 Jul 2006

Peskind Elaine R, Li Ge, Shofer Jane, Quinn Joseph F, Kaye Jeffrey A, Clark Chris M, Farlow Martin R, DeCarli Charles, Raskind Murray A, Schellenberg Gerard D, Lee Virginia M-Y, Galasko Douglas R

Abstract excerpt

BACKGROUND: Decreased cerebrospinal fluid (CSF) beta-amyloid 42 (A beta 42) concentration, but not A beta 40 concentration, is a biomarker for Alzheimer disease. This A beta 42 concentration decrease in CSF likely reflects precipitation of A beta 42 in amyloid plaques in brain parenchyma. This pathogenic plaque deposition begins years before the clinical expression of dementia in Alzheimer disease. Normal aging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Biomarkers

Share to Cognition

Share to Peptide Fragments

Source

Identifiers

PMID: 16831961
DOI: 10.1001/archneur.63.7.936

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition.PMID 16831961Read ↗

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrationsSemantic proximity Read ↗

Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEε4 genotype.Semantic proximity Read ↗

The effects of age, apolipoprotein E phenotype and gender on the concentration of amyloid-beta (A beta) 40, A beta 4242, apolipoprotein E and transthyretin in human cerebrospinal fluid.Semantic proximity Read ↗

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.Semantic proximity Read ↗

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.Semantic proximity Read ↗

Cerebrospinal beta-amyloid ((1-42)) in early Alzheimer's disease: association with apolipoprotein E genotype and cognitive decline.Semantic proximity Read ↗

Effects of amyloid pathology and the APOE ε4 allele on the association between cerebrospinal fluid Aβ38 and Aβ40 and brain morphology in cognitively normal 70-years-olds.Semantic proximity Read ↗

Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele.Semantic proximity Read ↗

Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimer's disease.Semantic proximity Read ↗

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.Semantic proximity Read ↗

Plasma and Cerebrospinal Fluid Levels of Amyloid β Proteins 1-40 and 1-42 in Alzheimer DiseaseSemantic proximity Read ↗

Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.