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Article

[Cell-ELA-based determination of binding affinity of DNA aptamer against U87-EGFRvIII cell].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 May 2013

Tan Yan, Liang Huiyu, Wu Xidong, Gao Yubo, Zhang Xingmei

Abstract excerpt

A15, a DNA aptamer with binding specificity for U87 glioma cells stably overexpressing the epidermal growth factor receptor variant III (U87-EGFRvIII), was generated by cell systematic evolution of ligands by exponential enrichment (cell-SELEX) using a random nucleotide library. Subsequently, we established a cell enzyme-linked assay (cell-ELA) to detect the affinity of A15 compared to an EGFR antibody. We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24010364

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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