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Article

Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model

16 Oct 2015

Abstract excerpt

An initial step in amyloid-β (Aβ) production includes amyloid precursor protein (APP) cleavage via β-Site amyloid precursor protein cleaving enzyme 1 (BACE1). Increased levels of brain Aβ have been implicated in the pathogenesis of Alzheimer's disease (AD). Thus, β-secretase represents a primary target for inhibitor drug development in AD. In this study, aptamers were obtained from combinatorial oligonucleotide...

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PMID: 26473367
DOI: 10.1371/journal.pone.0140733

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