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Article

CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for hepatitis C virus envelope glycoprotein E2.

PloS one - 3 Dec 2009

Chen Fang, Hu Yilan, Li Dongqing, Chen Haidan, Zhang Xiao-Lian

Abstract excerpt

Currently, the development of effective diagnostic reagents as well as treatments against Hepatitis C virus (HCV) remains a high priority. In this study, we have described the development of an alive cell surface--Systematic Evolution of Ligands by Exponential Enrichment (CS-SELEX) technique and screened the functional ssDNA aptamers that specifically bound to HCV envelope surface glycoprotein E2. Through 13...

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Identifiers

PMID: 19997645
DOI: 10.1371/journal.pone.0008142
PMCID: PMC2780912

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