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Article

Targeting Insulin Receptor with a Novel Internalizing Aptamer

1 Jan 2016

Abstract excerpt

Nucleic acid-based aptamers are emerging as therapeutic antagonists of disease-associated proteins such as receptor tyrosine kinases. They are selected by an in vitro combinatorial chemistry approach, named Systematic Evolution of Ligands by Exponential enrichment (SELEX), and thanks to their small size and unique chemical characteristics, they possess several advantages over antibodies as diagnostics and...

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Identifiers

PMID: 27648925
DOI: 10.1038/mtna.2016.73

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