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Article

SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis.

Annals of surgical oncology - 1 Jun 2012

Chen Hsieh-Cheng, Jeng Yung-Ming, Yuan Ray-Hwang, Hsu Hey-Chi, Chen Yu-Ling

Abstract excerpt

BACKGROUND: SIRT1 is a NAD+-dependent deacetylase that plays crucial roles in many biological processes, including stress response, apoptosis, cellular metabolism, adaptation to calorie restriction, aging, and tumorigenesis. The purpose of this study is to elucidate the clinicopathological and functional significance of SIRT1 expression in hepatocellular carcinoma (HCC). METHODS: SIRT1 expression in HCC was...

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Identifiers

PMID: 22146883
DOI: 10.1245/s10434-011-2159-4

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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