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DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

5 Sept 2013

Abstract excerpt

BACKGROUND: Genetic variants in the inhibiting FcγRIIB mediate anti-inflammatory responses and influence IVIG refractoriness (IVIG-R). However, these variants are rare in Asian and Hispanic populations so other genes in the pathway could be potentially involved. IVIG is ineffective in mice lacking SIGN-R1, a related molecule to human DC-SIGN. Further, DC-SIGN is a known receptor for sialylated Fc, the component...

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PMID: 24006904
DOI: 10.1186/1546-0096-11-32

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