Article
Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Hong Kong medical journal = Xianggang yi xue za zhi - 1 Aug 2008
Khoo U S, Chan K Y, Chan V S, Ching J C Y, Yam L, Chu C M, Lai S T, Wong T Y, Tam P, Yip S P, Leung G M, Lin C L, Peiris J S M
Abstract excerpt
1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous...
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