DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation.

doi:10.1371/journal.pntd.0000934

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Article

DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation.

PLoS neglected tropical diseases - 4 Jan 2011

Wang Lin, Chen Rong-Fu, Liu Jien-Wei, Lee Ing-Kit, Lee Chiu-Ping, Kuo Ho-Chang, Huang Shau-Ku, Yang Kuender D

Abstract excerpt

BACKGROUND: the C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) is susceptible to many infectious diseases. We reason that variations in the DC-SIGN gene might have a broad influence on viral replication and host immune responses. METHODS AND FINDINGS: we studied...

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PMID: 21245921
DOI: 10.1371/journal.pntd.0000934
PMCID: PMC3014977

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