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Article

Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.

Circulation. Cardiovascular genetics - 1 Jun 2012

Shrestha Sadeep, Wiener Howard, Shendre Aditi, Kaslow Richard A, Wu Jianming, Olson Aaron, Bowles Neil E, Patel Hitendra, Edberg Jeffrey C, Portman Michael A

Abstract excerpt

BACKGROUND: A functional polymorphism in the inhibitory IgG-Fc receptor gene FcγRIIB influences intravenous immunoglobulin (IVIG) response in Kawasaki disease (KD), a vasculitis preferentially affecting the coronary arteries in children. We tested the hypothesis that the polymorphisms in the activating receptors (FcγRIIA, FcγRIIIA, and FcγRIIIB) also influence susceptibility, IVIG treatment response, and coronary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22565545
DOI: 10.1161/CIRCGENETICS.111.962464
PMCID: PMC3444514

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