Article
DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility.
Human immunology - 1 Jun 2007
Boily-Larouche Geneviève, Zijenah Lynn S, Mbizvo Mike, Ward Brian J, Roger Michel
Abstract excerpt
Dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and DC-SIGNR are C-type lectins that serve both as cell adhesion and pathogen recognition receptors. Because of the essential role of the these molecules in the immune response, the implication of their alleles in human disease states, and the possible genetic variation at these loci among ethnically diverse populations, we...
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