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Article

Determination of DC-SIGN and DC-SIGNR repeat region variations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005

Liu Huanliang, Zhu Tuofu

Abstract excerpt

DC-SIGN and DC-SIGNR efficiently bind HIV-1 and other viral as well as nonviral pathogens and assist either cis or trans infection. Both are type II transmembrane proteins that consist of an N-terminal cytoplasmic domain, a repeat region consisting of seven 23-amino-acid tandem repeats, and a C-terminal C-type carbohydrate recognition domain that binds mannose-enriched carbohydrate modifications of host and...

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Identifiers

PMID: 16061998
DOI: 10.1385/1-59259-907-9:471

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