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Article

Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model.

Human molecular genetics - 15 Jan 2014

Nizzardo Monica, Simone Chiara, Rizzo Federica, Ruggieri Margherita, Salani Sabrina, Riboldi Giulietta, Faravelli Irene, Zanetta Chiara, Bresolin Nereo, Comi Giacomo P, Corti Stefania

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by the degeneration of motor neurons. Currently, there is no effective therapy for ALS. Stem cell transplantation is a potential therapeutic strategy for ALS, and the reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) represents a novel cell source. In this study, we isolated a specific neural stem cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24006477
DOI: 10.1093/hmg/ddt425
PMCID: PMC3869354

Genes

TRPV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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