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Article

Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.

Stem cells translational medicine - 1 Mar 2013

Popescu Iuliana Ristea, Nicaise Charles, Liu Song, Bisch Grégoire, Knippenberg Sarah, Daubie Valery, Bohl Delphine, Pochet Roland

Abstract excerpt

Human induced pluripotent stem cells (iPSCs) offer hope for personalized regenerative cell therapy in amyotrophic lateral sclerosis (ALS). We analyzed the fate of human iPSC-derived neural progenitors transplanted into the spinal cord of wild-type and transgenic rats carrying a human mutated SOD1(G93A) gene. The aim was to follow survival and differentiation of human neural progenitors until day 60...

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Source

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Identifiers

PMID: 23413376
DOI: 10.5966/sctm.2012-0042
PMCID: PMC3659761

Genes

SOD1
MAP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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