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Article

Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique.

Neurobiology of disease - 1 Oct 2015

Toli Diana, Buttigieg Dorothée, Blanchard Stéphane, Lemonnier Thomas, Lamotte d'Incamps Boris, Bellouze Sarah, Baillat Gilbert, Bohl Delphine, Haase Georg

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease. Human motor neurons generated from induced pluripotent stem cells (iPSc) offer new perspectives for disease modeling and drug testing in ALS. In standard iPSc-derived cultures, however, the two major phenotypic alterations of ALS--degeneration of motor neuron cell bodies and axons--are often obscured by cell body clustering,...

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PMID: 26107889
DOI: 10.1016/j.nbd.2015.06.011

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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