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Article

n-Butylidenephthalide recovered calcium homeostasis to ameliorate neurodegeneration of motor neurons derived from amyotrophic lateral sclerosis iPSCs.

PloS one - 1 Jan 2024

Deng Yu-Chen, Liu Jen-Wei, Ting Hsiao-Chien, Kuo Tzu-Chen, Chiang Chia-Hung, Lin En-Yi, Harn Horng-Jyh, Lin Shinn-Zong, Chang Chia-Yu, Chiou Tzyy-Wen

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that causes muscle atrophy and primarily targets motor neurons (MNs). Approximately 20% of familial ALS cases are caused by gain-of-function mutations in superoxide dismutase 1 (SOD1), leading to MN degeneration and ion channel dysfunction. Previous studies have shown that n-Butylidenephthalide (BP) delays disease progression and...

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Identifiers

PMID: 39509425
DOI: 10.1371/journal.pone.0311573
PMCID: PMC11542850

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