Article
Variability of clinical syndromes and cerebral glucose metabolism in symptomatic frontotemporal lobar degeneration associated with progranulin mutations.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2020
Licata Abigail, Grimmer Timo, Winkelmann Juliane, Wagner Matias, Goldhardt Oliver, Riedl Lina, Roßmeier Carola, Yakushev Igor, Diehl-Schmid Janine
Abstract excerpt
Objective: The aims of our study were to describe the clinical phenotype and to characterize the cerebral glucose metabolism patterns as measured with fluordesoxyglucose-positron emission tomography (FDG-PET) in symptomatic FTLD-patients with different GRN variants. Methods: For this study, data were included from all patients (n = 10) of a single-center FTLD registry study who had a pathogenic GRN variant and...
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