Article
Early neuropsychological characteristics of progranulin mutation carriers.
Journal of the International Neuropsychological Society : JINS - 1 Aug 2014
Hallam Bradley J, Jacova Claudia, Hsiung Ging-Yuek R, Wittenberg Dana, Sengdy Pheth, Bouchard-Kerr Phoenix, Slack Penny, Rademakers Rosa, Baker Matthew, Chow Tiffany W, Levine Brian, Feldman Howard H, Mackenzie Ian R
Abstract excerpt
Mutations in the progranulin gene (GRN) are a common cause of familial frontotemporal dementia. We used a comprehensive neuropsychological battery to investigate whether early cognitive changes could be detected in GRN mutation carriers before dementia onset. Twenty-four at-risk members from six families with known GRN mutations underwent detailed neuropsychological testing. Group differences were investigated by...
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