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Article

Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes.

Current diabetes reports - 1 Oct 2013

Storling Joachim, Brorsson Caroline Anna

Abstract excerpt

In type 1 diabetes (T1D), the insulin-producing β cells are destroyed by an immune-mediated process leading to complete insulin deficiency. There is a strong genetic component in T1D. Genes located in the human leukocyte antigen (HLA) region are the most important genetic determinants of disease, but more than 40 additional loci are known to significantly affect T1D risk. Since most of the currently known genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23925433
DOI: 10.1007/s11892-013-0408-6

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