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Article

Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM.

Frontiers in endocrinology - 1 Jan 2020

Pang Haipeng, Luo Shuoming, Huang Gan, Xia Ying, Xie Zhiguo, Zhou Zhiguang

Abstract excerpt

T1DM (type 1 diabetes mellitus), which results from the irreversible elimination of beta-cells mediated by autoreactive T cells, is defined as an autoimmune disease. It is widely accepted that T1DM is caused by a combination of genetic and environmental factors, but the precise underlying molecular mechanisms are still unknown. To date, more than 50 genetic risk regions contributing to the pathogenesis of T1DM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32226409
DOI: 10.3389/fendo.2020.00119
PMCID: PMC7080653

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