Article
A reducing milieu renders cofilin insensitive to phosphatidylinositol 4,5-bisphosphate (PIP2) inhibition.
The Journal of biological chemistry - 11 Oct 2013
Schulte Bianca, John Isabel, Simon Bernd, Brockmann Christoph, Oelmeier Stefan A, Jahraus Beate, Kirchgessner Henning, Riplinger Selina, Carlomagno Teresa, Wabnitz Guido H, Samstag Yvonne
Abstract excerpt
Oxidative stress can lead to T cell hyporesponsiveness. A reducing micromilieu (e.g. provided by dendritic cells) can rescue T cells from such oxidant-induced dysfunction. However, the reducing effects on proteins leading to restored T cell activation remained unknown. One key molecule of T cell activation is the actin-remodeling protein cofilin, which is dephosphorylated on serine 3 upon T cell costimulation and...
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