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Article

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2006

Kennedy Richard D, D'Andrea Alan D

Abstract excerpt

Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair. Cancer cells are often defective in one of six major DNA repair pathways, namely: mismatch repair, base excision repair, nucleotide excision repair, homologous recombination, nonhomologous endjoining and translesion synthesis. The specific DNA repair pathway affected is predictive of the kinds of...

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Identifiers

PMID: 16896009
DOI: 10.1200/JCO.2005.05.4171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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