Inhibition of G-quadruplex assembling by DNA ligation: a versatile and non-covalent labeling strategy for bioanalysis.

Abstract excerpt

Through tuning relative thermodynamic stabilities (I, II and III), DNA ligation was coupled to split G-quadruplex probes and a versatile, non-covalent labelling and fluorescent strategy was constructed based on inhibition of template-directed G-quadruplex assembling by ligation reaction. The non-covalent complex between G-quadruplex and fluorescent probe was employed as signalling label and thus covalent...

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