Article
Rag mutations reveal robust alternative end joining.
Nature - 27 Sept 2007
Corneo Barbara, Wendland Rebecca L, Deriano Ludovic, Cui Xiaoping, Klein Isaac A, Wong Serre-Yu, Arnal Suzzette, Holub Abigail J, Weller Geoffrey R, Pancake Bette A, Shah Sundeep, Brandt Vicky L, Meek Katheryn, Roth David B
Abstract excerpt
Mammalian cells repair DNA double-strand breaks (DSBs) through either homologous recombination or non-homologous end joining (NHEJ). V(D)J recombination, a cut-and-paste mechanism for generating diversity in antigen receptors, relies on NHEJ for repairing DSBs introduced by the Rag1-Rag2 protein complex. Animals lacking any of the seven known NHEJ factors are therefore immunodeficient. Nevertheless, DSB repair is...
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