Article
A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2015
Delahaye-Sourdeix Manon, Urayama Kevin Y, Gaborieau Valérie, Veenstra Rianne, Foll Matthieu, Chabrier Amelie, Benavente Yolanda, Nieters Alexandra, Becker Nikolaus, Foretova Lenka, Maynadié Marc, Staines Anthony, Smedby Karin Ekstrom, Glimelius Ingrid, Lightfoot Tracy, Cocco Pierluigi, Galan Pilar, Vatten Lars J, Duell Eric J, Kiemeney Lambertus, Roman Eve, de Sanjosé Silvia, Lathrop Mark, Melbye Mads, Brennan Paul, Diepstra Arjan, van den Berg Anke, Hjalgrim Henrik, Jarrett Ruth F, McKay James D
Abstract excerpt
BACKGROUND: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein-Barr virus (EBV) status, particularly within the MHC region. METHODS: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in...
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