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Article

Histone variant HTZ1 shows extensive epistasis with, but does not increase robustness to, new mutations.

PLoS genetics - 1 Jan 2013

Richardson Joshua B, Uppendahl Locke D, Traficante Maria K, Levy Sasha F, Siegal Mark L

Abstract excerpt

Biological systems produce phenotypes that appear to be robust to perturbation by mutations and environmental variation. Prior studies identified genes that, when impaired, reveal previously cryptic genetic variation. This result is typically interpreted as evidence that the disrupted gene normal...

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Share to Acetylation
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Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23990806
DOI: 10.1371/journal.pgen.1003733
PMCID: PMC3749942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23990806-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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