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Article

Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy.

American journal of hematology - 1 Mar 2025

Hallek Michael

Abstract excerpt

DISEASE OVERVIEW: Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia. It typically occurs in older patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and apoptosis in clonal B-cells. DIAGNOSIS: The diagnosis is established by blood counts, blood smears, and...

Topics

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BCL2 gene
BTK gene
TP53 gene
Leukemia, Lymphocytic, Chronic, B-Cell
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39871707
DOI: 10.1002/ajh.27546
PMCID: PMC11803567

Genes

BCL2
BTK
CD5
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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