Article
CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes.
American journal of physiology. Renal physiology - 1 Apr 2025
Sun Yingyu, Kronenberg Nils M, Sethi Sidharth K, Dash Surjya N, Kovalik Maria E, Sempowski Benjamin, Strickland Shelby, Raina Rupesh, Sperati C John, Tian Xuefei, Ishibe Shuta, Hall Gentzon, Gather Malte C
Abstract excerpt
Focal segmental glomerulosclerosis (FSGS) is a histologic lesion caused by a variety of injurious stimuli that lead to dysfunction/loss of glomerular visceral epithelial cells (i.e., podocytes). Pathogenic mutations in crumbs homolog-2 (CRB2), encoding the type 1 transmembrane protein crumbs homolog-2, have been shown to cause early-onset corticosteroid-resistant nephrotic syndrome (SRNS)/FSGS. Here, we...
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