Article

CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes

2024-10-25

Abstract excerpt

Focal Segmental Glomerulosclerosis (FSGS) is a histologic lesion caused by a variety of injurious stimuli that lead to dysfunction/loss of glomerular visceral epithelial cells (i.e. podocytes). Pathogenic mutations in CRB2, encoding the type 1 transmembrane protein Crumb 2 Homolog Protein, have been shown to cause early-onset corticosteroid-resistant nephrotic syndrome (SRNS)/FSGS. Here, we identified a 2-generati...

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Literature Corpus work: 209fbe03-6281-52df-a7ed-89b791bf38fe
DOI: 10.1101/2024.10.22.619513

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