Article
Diversity of the murine antibody response targeting influenza A(H1N1pdm09) hemagglutinin.
Virology - 1 Jun 2014
Wilson Jason R, Tzeng Wen-Pin, Spesock April, Music Nedzad, Guo Zhu, Barrington Robert, Stevens James, Donis Ruben O, Katz Jacqueline M, York Ian A
Abstract excerpt
UNLABELLED: We infected mice with the 2009 influenza A pandemic virus (H1N1pdm09), boosted with an inactivated vaccine, and cloned immunoglobulins (Igs) from HA-specific B cells. Based on the redundancy in germline gene utilization, we inferred that between 72-130 unique IgH VDJ and 35 different IgL VJ combinations comprised the anti-HA recall response. The IgH VH1 and IgL VK14 variable gene families were...
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