Article
A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1990
Kavaler J, Caton A J, Staudt L M, Schwartz D, Gerhard W
Abstract excerpt
Approximately 50% of the primary antibody response of BALB/c mice to the A/PR/8/34 influenza virus hemagglutinin is directed to the Cb site, one of the four major antigenic regions of the molecule. To determine the structural basis of the anti-Cb site response, we have examined the paratypic and genetic diversity exhibited by a panel of 24 primary and 4 secondary response mAb specific for this antigenic region....
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