A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1990

Kavaler J, Caton A J, Staudt L M, Schwartz D, Gerhard W

Abstract excerpt

Approximately 50% of the primary antibody response of BALB/c mice to the A/PR/8/34 influenza virus hemagglutinin is directed to the Cb site, one of the four major antigenic regions of the molecule. To determine the structural basis of the anti-Cb site response, we have examined the paratypic and genetic diversity exhibited by a panel of 24 primary and 4 secondary response mAb specific for this antigenic region....

Topics

Amino Acid Sequence
Animals
Antibodies, Viral
Antibody Diversity
Antibody Specificity
Antigens, Viral
Base Sequence
Genes, Immunoglobulin
Hemagglutinins, Viral
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Immunoglobulin kappa-Chains

Influenza A virus

Mice

Mice, Inbred BALB C

Models, Molecular

Mutation

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 2118933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2118933-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.PMID 2118933Read ↗

The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.Semantic proximity Read ↗

V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.Semantic proximity Read ↗

Serological analysis of H-2 mutations using monoclonal antibodies.Semantic proximity Read ↗

Germline diversity of the expressed BALB/c VhJ558 gene family.Semantic proximity Read ↗

Analysis of the anti-azobenzenearsonate response at the molecular level.Semantic proximity Read ↗

Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice.Semantic proximity Read ↗

Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virus.Semantic proximity Read ↗

Isolates of Candida albicans that differ in virulence for mice elicit strain-specific antibody-mediated protective responses.Semantic proximity Read ↗

Humoral immune responses to systemic Candida albicans infection in inbred mouse strains.Semantic proximity Read ↗

Kinetic and genetic bases for the heteroclitic recognition of mouse cytochrome c by mouse anti-pigeon cytochrome c monoclonal antibodies.Semantic proximity Read ↗

A mouse monoclonal antibody specific for an allotypic determinant of the Igha allele of murine IgM: genetic and functional analysis of Igh-6a epitopes using anti-IgM monoclonal antibodies.Semantic proximity Read ↗

[The heterogeneity of an influenza virus A population in its capacity to induce the synthesis of avid antibodies].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.