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Article

Monophosphoryl lipid A induces bone marrow precursor cells to differentiate into myeloid-derived suppressor cells.

Molecular medicine reports - 1 Oct 2013

Chen Jie, Sun Baomu, Zhao Xiuhua, Liang Dong, Liu Junxia, Huang Yong, Lei Wanke, Chen Maomao, Sun Weimin

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs) are important in the immune response. In vitro, DCs are derived from myeloid precursors by stimulation with granulocyte macrophage colony‑stimulating factor and interleukin‑4. Previous studies demonstrated that lipopolysaccharide (LPS) in combination with interferon‑γ inhibited DC development but enhanced MDSC functions. Monophosphoryl lipid A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23982165
DOI: 10.3892/mmr.2013.1653

Genes

MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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