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Article

Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors.

Cellular & molecular immunology - 1 Mar 2014

Li Qian, Han Dongmei, Wang Wei, Liu Xiaoqing, Sun Xiuyuan, Zhang Jun, Li Rong, Zhang Yu

Abstract excerpt

Lipopolysaccharide (LPS) is known to be a potent activator of mature B cells by signaling through Toll-like receptor 4 (TLR4). Its impact on early B-cell development, however, is not well defined. When comparing to C3H/HeN mice, TLR4-mutant C3H/HeJ mice showed an increase in the number of pro-B and pre-B cells in the bone marrow. When cultured in the presence of IL-7, the proliferation of pro-B and large pre-B...

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Identifiers

PMID: 24317301
DOI: 10.1038/cmi.2013.55
PMCID: PMC4003377

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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