Article
Lipoxin A4 negatively regulates lipopolysaccharide-induced differentiation of RAW264.7 murine macrophages into dendritic-like cells.
Chinese medical journal - 5 Jun 2007
Zhang Li, Wu Ping, Jin Sheng-wei, Yuan Ping, Wan Jing-yuan, Zhou Xiao-yan, Xiong Wei, Fang Feng, Ye Du-yun
Abstract excerpt
BACKGROUND: Lipoxins (LXs), endogenous anti-inflammatory and pro-resolving eicosanoids generated during various inflammatory conditions, have novel immunomodulatory properties. Because dendritic cells (DCs) play crucial roles in the initiation and maintenance of immune response, we determined whether LXs could modulate the maturation process of DCs and investigated the effects of lipoxin A(4) (LXA(4)) on...
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