Article
Fc gamma receptor 3A polymorphism and risk for HIV-associated cryptococcal disease.
mBio - 27 Aug 2013
Rohatgi Soma, Gohil Shruti, Kuniholm Mark H, Schultz Hannah, Dufaud Chad, Armour Kathryn L, Badri Sheila, Mailliard Robbie B, Pirofski Liise-anne
Abstract excerpt
UNLABELLED: Cryptococcus neoformans is one of the most common causes of fungal disease in HIV-infected persons, but not all of those who are infected develop cryptococcal disease (CD). Although CD4(+) T cell deficiency is a risk factor for HIV-associated CD, polymorphisms of phagocytic Fc gamma receptors (FCGRs) have been linked to CD risk in HIV-uninfected persons. To investigate associations between FCGR2A 131...
Topics
- AIDS-Related Opportunistic Infections
- Adult
- Antibody-Dependent Cell Cytotoxicity
- CD4 Lymphocyte Count
- Cohort Studies
- Cryptococcosis
- Cryptococcus neoformans
- Genotype
- Humans
- Killer Cells, Natural
- Male
- Middle Aged
- Mutation, Missense