Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.

PloS one - 1 Jan 2013

Phuah Sze Yee, Lee Sheau Yee, Kang Peter, Kang In Nee, Yoon Sook-Yee, Thong Meow Keong, Hartman Mikael, Sng Jen-Hwei, Yip Cheng Har, Taib Nur Aishah Mohd, Teo Soo-Hwang

Abstract excerpt

BACKGROUND: The partner and localizer of breast cancer 2 (PALB2) is responsible for facilitating BRCA2-mediated DNA repair by serving as a bridging molecule, acting as the physical and functional link between the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) proteins. Truncating mutations in the PALB2 gene are rare but are thought to be associated with increased risks of developing breast cancer in various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ethnicity
Share to Family

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

Share to Germ-Line Mutation

Share to Malaysia

Share to Nuclear Proteins

Share to Singapore

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23977390
DOI: 10.1371/journal.pone.0073638
PMCID: PMC3748013

Genes

PALB2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.PMID 23977390Read ↗

Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.Semantic proximity Read ↗

Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.Semantic proximity Read ↗

PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia.Semantic proximity Read ↗

Novel germline PALB2 truncating mutations in African American breast cancer patients.Semantic proximity Read ↗

Rare germline mutations in PALB2 and breast cancer risk: a population-based study.Semantic proximity Read ↗

Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer.Semantic proximity Read ↗

PALB2 mutations in familial breast and pancreatic cancer.Semantic proximity Read ↗

Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.