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Article

Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.

PloS one - 1 Jan 2013

Phuah Sze Yee, Lee Sheau Yee, Kang Peter, Kang In Nee, Yoon Sook-Yee, Thong Meow Keong, Hartman Mikael, Sng Jen-Hwei, Yip Cheng Har, Taib Nur Aishah Mohd, Teo Soo-Hwang

Abstract excerpt

BACKGROUND: The partner and localizer of breast cancer 2 (PALB2) is responsible for facilitating BRCA2-mediated DNA repair by serving as a bridging molecule, acting as the physical and functional link between the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) proteins. Truncating mutations in the PALB2 gene are rare but are thought to be associated with increased risks of developing breast cancer in various...

Topics

Adult
Asian People
Case-Control Studies
DNA Mutational Analysis
Ethnicity
Exons
Family
Fanconi Anemia Complementation Group N Protein
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Humans

Malaysia

Male

Middle Aged

Nuclear Proteins

Pedigree

Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 23977390
DOI: 10.1371/journal.pone.0073638
PMCID: PMC3748013

Genes

PALB2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.PMID 23977390Read ↗

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